In flocy iritis floppy syndrome ( IFIS ) is a possible complication during cataract extraction in certain patients. This syndrome is characterized by overflowing mushy irises in response to ordinary intraocular fluid flow, a tendency for this iris floppy to prolapse to the cataract extraction area during surgery, and progressive intraoperative pupillary constriction despite standard procedures to prevent this.
IFIS has been associated with tamsulosin (eg, Flomax), a drug widely prescribed for urinary symptoms associated with benign prostatic hyperplasia (BPH). Tamsulosin is a selective alpha blocker that works by relaxing the bladder and smooth muscle of the prostate. Thus, it also relaxes the iris dilator muscles by binding the ends of the postnasinaps nerve. Various alpha-blockers are associated with IFIS, but tamsulosin has a stronger association than others.
A joint statement from the two ophthalmological communities states that "another major class of drugs for treating BPH - a 5-alpha-reductase inhibitor - does not seem to cause IFIS at a significant level." 5-ARIS includes finasteride, a drug commonly used as first-line therapy for BPH and androgenic alopecia. This drug is also associated with cataract formation.
IFIS can also be associated with other causes of small pupils such as synechiae, pseudoexfoliation and other drugs (used for conditions such as glaucoma, diabetes and high blood pressure). IFIS usually does not cause significant changes in postoperative outcomes. Patients may experience more pain, longer recovery periods, and a slight increase in visual acuity than patients with uncomplicated cataract removal.
The severity of this condition is not related to the duration of tamsulosin intake.
Video Intraoperative floppy iris syndrome
References
Maps Intraoperative floppy iris syndrome
External links
Source of the article : Wikipedia
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